Compound of silver and nucleinic acids.



UNITED sir-Arts PATENT, OFFICE.

OTTO DEGNER, OF ELBERFELD, GERMANY, ASSIGNQR TO FARBENFABRI- KEN VORM. FRIEDR. BAYER 8000.", OF ELBERFELD, GERMANY, A COR PORATION OF GERMAN Y.

OOIVIPOUND OF' SILVER AND NUCLE INIC ACIDS Specification of Letters Patent.

raten'ted May 7, 1907.

Application filed April 17,1906. Serial No. 812.176- (Speoimena) I To all whom it may concern:

Be it known that I, O'r'ro DEGNER, doctor of philosophy, chemist, a citizen of the German Empire, residing at Elberfeld, Germany, Kingdom of Prussia, have invented new and useful Improvements in Compounds of Silver and Nucleinic Acids, of which the following is a specification.

My invention relates to the production of new soluble compounds of nucleinic' acids and silver. The process for the preparation of these bodies consists in treating the m-.

soluble silver compounds of nucleinic acids or salts thereof with neutral-salt solutions.

Under the expression nucleinic acids I understand nucleinic acids of animal or vegetable origin, as they are obtained e. g. from yeast, sperm, thymus, etcl and which are distinguished from albumen, etc. as follows: (Colmheim0hemie dcr E'iwc'isslcfirper, II. Aufiage, 1904, page 221): I

Nucleo pigeid Albumen nuclein (Histon) Albumen nucleinic acid.

The new silver compounds contain more than per cent of silver which silver con-.

tent is characteristic of the silver salts of nucleinic acid of the old art as described for example in German Patent No. 118,050. My new salts contain from to per cent. of silver. They are, when dry and pulverized, yellowish powders soluble in water with a yellowish-brown color and insoluble in ether and benzene. They contain the sil: ver so firmly combined with the nucleinic acid molecule that on adding a diluted solution ofcaustic soda lye or a solution of com:

mon salt to the aqueous solution of the new silver compounds no precipitate is obtained. The new products possess valuable therapeutic properties as antiseptics and their freedom from irritation renders their application highly satisfactory. A solution of from 2 to 3 per cent may be used for external application.

In carrying out my new process practically I can proceed as follows, the parts being by weight:

Example 1. parts of silver nitrate dissolved in water are stirred into a solution of until a clear solution results.

100 parts of the sodium salt of nucleinic acid from yeast in 300 parts of water. A voluminous precipitate is obtained to which a satu rated solution of common salt is slowly added The soluble silver com ound thus obtained is separated from its so ution by the addition of alcohol, filtered off, washed several times with alcohol and dried in vacuo. It is a, yellowishwhite powder having the above mentioned properties and containing from 22 to 23 per cent of silver.

Example 2. 100 parts of the sodium salt of nucleinic acid from yeast are dissolved in 300 parts of water, and to this solution a watery solution of 30 arts of nitrate of-silver is added with stn'ring. A voluminous preci itate is obtained to which. a saturated so ution of common salt is slowly added until aclear solution results. The soluble silver compound thus obtained is separated from its solution by the addition of alcohol, filtered ofi, washed several times with alcohol, and dried in cacum It is a yellowish-white powder, having theabove-mentioned properties, and containing 15% of silver.

Example 3. 100 parts of the sodium salt of nucleinic acid from yeast are dissolved in 300 parts of water, and tothis solution a watery solution of parts ofnitrate of silver is added with stirring. A voluminous precipitate is obtained to which a saturated solution of common salt-is. slowly added until a clear solution results. The soluble silver compound thus obtainedjis separated from its solution by the addition of alcohol, filtered 0H, Washed several times with alcohol, and dried in 'vacuo. It is a yellowish-white powder, having the above-mentioned properties, and containing 25% of silver.

The process is carried out 1n an analogous silver-compounds are, when dry and. pulver-' ized, yellowish powders soluble in water with compound of nucleinic acid his compounds of titi clifiio' acids, R which new 'from yeast;and is, when and pulverized,

a yellowish-brown color, insoluble in ether and vbenzene, and containing the silver so firmly combined with the nucleinic acid molecule that the aqueous solutions do not give any precipitate on the addition of dilute caustic soda lye or a solution of common salt and 1 10 being valuable antiseptics, substantially as described.

2. The herein described new specific silver containing about 22 per cent. of silver, obtained from yeast, w ch new silver compound is obtainable by action of a common salt solutionon the insoluble silver com ound of niicleinic acid a yellowish powder, soluble in water with a 'ellow1sh=brown color,- insoluble in ether and enzene, and containing the silver so firmly combined with the nucleinic acid molecule that the aqueous solutlon does not give any precipitate on the addition of dilute caustic soda ye or a solution ofcommon salt; and being a valuable antiseptic, substantially as described. i a

In testimony whereof I have hereunto set my hand in the presence of two subscribing witnesses.

a, I .OTTO DEGNER. Witnesses:

Orro KoNIo, ARTHUR MATrHKws. 

